Publications
Most Recent
- N. Vale, C. Alves, V. Sharma, D. F. Lázaro, S. Silva, P. Gomes, T. Fleming Outeiro
A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
Pharmacological Reports, 72, 456–464 (2020).
doi: 10.1007/s43440-019-00032-x.pdf - C. Teixeira, C. Ventura, J. R. B. Gomes, P. Gomes, F. Martins
Cinnamic derivatives as antitubercular agents: characterization by quantitative structure-activity relationship studies.
Molecules, 25:456 (2020).
doi: 10.3390/molecules25030456 - S. de Albuquerque, L. Cianni, D. de Vita, C. Duque, A. S. M. Gomes, P. Gomes, C. Laughton, A. Leitão, C. A. Montanari, R. Montanari, J. F. R. Ribeiro, J. S. da Silva, C. Teixeira
Molecular Design Aided by Random Forests and Synthesis of Potent Trypanocidal Agents as Cruzain Inhibitors for Chagas Disease Treatment.
Chemical Biology and Drug Design, accepted (2020).
doi: - - A. Mangoni, et al.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 6 (editorial).
Molecules, 25: 119 (2020).
doi: 10.3390/molecules25010119 - A. T. Silva, C. M. Bento, A. C. Pena, L. M. Figueiredo, C. Prudêncio, L. Aguiar, T. Silva, R. Ferraz, M. S. Gomes, C. Teixeira, P. Gomes
Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs.
Molecules, 25:66 (2020).
doi: 10.3390/molecules2501066 - L. Aguiar, A. Biosca, E. Lantero, J. Gut, N. Vale, P. J. Rosenthal, F. Nogueira, D. Andreu, X. Fernández-Busquets, P. Gomes
Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates.
Molecules, 24:4559 (2019).
doi: 10.3390/molecules24244559 - P. Parreira, C. Monteiro, V. Graça, J. Gomes, S. Maia, P. Gomes , I. C. Gonçalves, M. C. L. Martins
Surface Grafted MSI-78A Antimicrobial Peptide has High Potential for Gastric Infection Management.
Scientific Reports - Nature, 9: 18212 (2019).
doi: 10.1038/s41598-019-53918-4 - N. Mariz-Ponte, C. V. Correia, C. Teixeira, P. Gomes, C. Santos
Doença do lenho do kiwi - esca, contexto e desafios.
Agrotec, 33: 14-16 (2019).
- B. Mendes, J. R. Almeida, N. Vale, P. Gomes, F. R. Gadelha, S. L. da Silva, D. Miguel
Potential use of 13-mer peptides based on phospholipase and oligoarginine as leishmanicidal agents.
Comparative Biochemistry and Physiology, Part C, 226: 108612 (2019).
doi: 10.1016/j.cbpc.2019.108612 - A. Gomes, L. J. Bessa, I. Fernandes, R. Ferraz, N. Mateus, P. Gameiro, C. Teixeira, and P. Gomes
Turning a collagenesis-inducing peptide into a potent antibacterial and antibiofilm agent against multidrug-resistant Gram-negative bacteria.
Frontiers in Microbiology, 10: 1915 (2019).
doi: 10.3389/fmicb.2019.01915 - C. Teixeira and P. Gomes
The Xylella fastidiosa global threat: can antimicrobial peptides help in tackling this menace?
Chimica Oggi - Chemistry Today, 37, 42-44 (2019).
- C. S. M. Fernandes, A. S. Pina, A. J. M. Barbosa, I. Padrão, F. Duarte, C. Teixeira, V. Alves, P. Gomes, T. G. Fernandes, A. M. G. C. Dias, A. C. Roque
Affinity-triggered assemblies based on a designed peptide-peptide affinity pair
Biotechnology Journal, ahead-of-print (2019).
doi: 10.1002/biot.201800559 - A. Mangoni, et al.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 5 (editorial).
Molecules, 24: 2415 (2019).
doi: 10.3390/molecules24132415 - M. Fonte, N. Fagundes, A. Gomes, R. Ferraz, C. Prudêncio, M. J. Araújo, P. Gomes, C. Teixeira
Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: on the way to multi-stage antimalarials.
Tetrahedron Letters, 60, 1166-1169 (2019).
doi: 10.1016/j.tetlet.2019.03.052 - A. T. Silva, M. J. Cerqueira, C. Prudêncio, M. H. Fernandes, J. Costa-Rodrigues, C. Teixeira, P. Gomes, R. Ferraz
Antiproliferative organic salts against cancer: disclosure of an ionic liquid selective against lung and liver cells.
ACS Omega, 4, 5682-5689 (2019).
doi: 10.1021/acsomega.8b03691 - A. R. Dias, J. Costa-Rodrigues, C. Teixeira, P. Gomes, C. Prudêncio, R. Ferraz
Ionic liquids for topical delivery in cancer.
Current Medicinal Chemistry, ahead-of-print (2019).
doi: 10.2174/0929867325666181026110227 - L. Aguiar, M. Machado, M. Sanches-Vaz, M. Prudêncio, N. Vale, P. Gomes
Coupling the cell-penetrating peptides Transportan and Transportan 10 to primaquine enhances its activity against liver-stage malaria parasites.
MedChemComm, 10, 221-226 (2019).
doi: 10.1039/C8MD00447A - A. Mangoni, et al.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 4 (editorial).
Molecules, 24: 130 (2019).
doi: 10.3390/molecules24010130 - J. Durão, N. Vale, S. Gomes, P., P. Gomes, C. Barrias, L. Gales
Nitric oxide release from antimicrobial peptide hydrogels for wound healing.
Biomolecules, 9:4 (2019).
doi: 10.3390/biom9010004 - M. Barbosa, F. Costa, C. Monteiro, F. Duarte, M. C. L. Martins, P. Gomes
Antimicrobial coatings prepared from Dhvar-5-click-grafted chitosan powders.
Acta Biomaterialia, 84, 242-256 (2019).
doi: 10.1016/j.actbio.2018.12.001 - J. Almeida, A. L. V. Palacios, R. S. P. Palma, B. Mendes, C. A. S. Teixeira, P. Gomes, S. L. da Silva
Harnessing snake venom phospholipases A2 to novel approaches for overcoming antibiotic resistance.
Drug Development Research, 80, 68-85 (2019).
doi: 10.1002/ddr.21456 - A. Mangoni, et al.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 3 (editorial).
Molecules, 23: 1596 (2018).
doi: 10.3390/molecules23071596 - C. Morais, A. Cardoso, P. Cunha, L. Aguiar, N. Vale, E. Lage, M. Pinheiro, C. Nunes, P. Gomes, S. Reis, M. M. Castro, M. C. Pedroso de Lima, M. A. S. Jurado
Acylation of the S413-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: relevance of peptide/lipid interactions.
Biochimica et Biophysica Acta - Biomembranes, 1860, 2619-2634 (2018).
doi: 10.1016/j.bbamem.2018.10.002 - A. Gomes, R. Ferraz, L. Ficker, M. S. Collins, C. Prudêncio, M. T. Cushion, C. A. S. Teixeira, P. Gomes
Chloroquine analogues as leads against Pneumocystis lung pathogens.
Antimicrobial Agents and Chemotherapy, 62, e00983-18 (2018).
doi: 10.1128/AAC.00983-18 - J. Almeida, B. Mendes, M. Lancellotti, S. Marangoni, N. Vale, O. Passos, M. J. Ramos, P. Fernandes, P. Gomes, S. L. da Silva
A novel synthetic peptide inspired on Lys49 phospholipase A2 from Crotalus oreganys abyssus snake venom active against multidrug-resistant clinical isolates.
European Journal of Medicinal Chemistry, 149, 248-256 (2018).
doi: 10.1016/j.ejmech.2018.02.055 - T. Silva, B. Claro, B. F. B. Silva, N. Vale, P. Gomes, M. S. Gomes, S. S. Funari, J. Teixeira, D. Uhríková, M. Bastos
Unravelling a Mechanism of Action for a Cecropin A- Melittin Hybrid Antimicrobial Peptide: The Induced Formation of Multilamellar Lipid Stacks.
Langmuir, 34, 2158-2170 (2018).
doi: 10.1021/acs.langmuir.7b03639 - L. J. Bessa, P. Eaton, A. Dematei, A. Plácido, N. Vale, P. Gomes, C. Delerue-Matos, J. Leite, P. Gameiro
Synergistic and antibiofilm properties of ocellatin peptides against multidrug-resistant Pseudomonas aeruginosa.
Future Microbiology, 13, 151-163 (2018).
doi: 10.2217/fmb-2017-0175 - E. Barbosa, A. Oliveira, A. Plácido, R. Socodato, C. C. Portugal, A. C. Mafud, A. S. Ombredane, D. C. Moreira, N. Vale, L. J. Bessa, G. A. Joanitti, C. Alves, P. Gomes, C. Delerue-Matos, Y. P. Mascarenhas, M. M. Marani, J. B. Relvas, M. Pintado, J. Leite
Structure and Function of a Novel Antioxidant Peptide from the Skin of Tropical Frogs.
Free Radical Biology and Medicine, 115, 68-79 (2018).
doi: 10.1016/jfreeradbiomed.2017.11.001 - F. Costa, D. Sousa, M. Lamghari, P. Parreira, P. Gomes, C. Martins
N-acetyl cysteine covalent immobilization prevents bacterial adhesion without impairing cellular adhesion and proliferation.
Scientific Reports - Nature, 7, Article number: 17374 (2017).
doi: 10.1038/s41598-017-17310-4 - S. Galdiero, P. Gomes
Peptide-Based Drugs and Drug Delivery Systems (editorial).
Molecules, 22:2185 (2017).
doi: 10.3390/molecules22122185 - A. Gomes, C. Teixeira, R. Ferraz, C. Prudêncio, P. Gomes
Wound-healing peptides for treatment of chronic diabetic foot ulcers and other infected skin injuries.
Molecules, 22:1743 (2017).
doi: 10.3390/molecules22101743 - T. Silva, A. Moreira, K. Nazmi, T. Moniz, N. Vale, M. Rangel, P. Gomes, J. Bolscher, P. Rodrigues, M. Bastos, M. S. Gomes
Lactoferricin peptides increase macrophage's capacity to kill Mycobacterium avium.
mSphere, 2:e00301-17 (2017).
doi: 10.1128/mSphere.00301-17 - D. D. R. Arcanjo, A. G. Vasconcelos, L. A. Nascimento, A. C. Mafud, A. Plácido, M. M. M. Alves, C. Delerue-Matos, M. P. Bemquerer, N. Vale, P. Gomes, E. B. Oliveira, F. C. A. Lima, Y. P. Mascarenhas, F. A. A. Carvalho, U. Simonsen, R. M. Ramos, J. R. S. A. Leite
Structure-function studies of BPP-BrachyNH2 and synthetic analogues thereof with Angiotensin I-Converting enzyme.
European Journal of Medicinal Chemistry, 139, 401-411 (2017).
doi: 10.1016/j.ejmech.2017.08.019 - E. Moles, S. Galiano, A. Gomes, M. Quiliano, C. Teixeira, I. Aldana, P. Gomes, X. Fernández-Busquets
ImmunoPEGliposomes for the targeted delivery of novel lipophilic drugs to red blood cells in a falciparum malaria murine model.
Biomaterials, 145, 178-191 (2017).
doi: 10.1016/j.biomaterials.2017.08.020 - R. Ferraz, M. Pinheiro, C. Teixeira, A. Gomes, C. Prudêncio, S. Reis, P. Gomes
Effects of novel triple-stage antimalarial ionic liquids on lipid membrane models.
Bioorganic and Medicinal Chemistry Letters, 27, 4190-4193 (2017).
doi: 10.1016/j.bmcl.2017.07.006 - N. Vale, A. Ferreira, I. Fernandes, C. Alves, M. J. Araújo, N. Mateus, P. Gomes
Gemcitabine anti-proliferative activity significantly enhanced upon conjugation with cell-penetrating peptides.
Bioorganic and Medicinal Chemistry Letters, 27, 2898-2901 (2017).
doi: 10.1016/j.bmcl.2017.04.086 - S. Almeida Dias, J. M. Freire, C. Pérez-Peinado, M. M. Domingues, D. Gaspar, N. Vale, P. Gomes, D. Andreu, S. Troeira Henriques, M. Castanho, A. S. Veiga
New potent membrane-targeting antibacterial peptides from viral capsid proteins.
Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy 8: 775 (2017).
doi: 10.3389/fmicb.2017.00775 - R. Ferrer-Gallego, J. M. Hernández-Hierro, N. F. Brás, N. Vale, P. Gomes, N. Mateus, V. de Freitas, F. J. Heredia, M. Teresa Escribano-Bailón
Interaction between wine phenolic acids and salivary proteins by STD-NMR and molecular dynamics simulations.
Journal of Agricultural and Food Chemistry, 65, 6434–6441 (2017).
doi: 10.1021/acs.jafc.6b05414 - M. Barbosa, N. Vale, F. M. T. A. Costa, M. C. L. Martins, P. Gomes
Tethering antimicrobial peptides onto chitosan: optimization of azide-alkyne “click” reaction conditions
Carbohydrate Polymers, 165, 384-393 (2017).
doi: 10.1016/j.carbpol.2017.02.050
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