Publications
Past 5 years
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M. Fonte, et al.
Disclosure of cinnamic acid/4,9-diaminoacridine conjugates as multi-stage antiplasmodial hits.
Bioorganic & Medicinal Chemistry, ahead-of-print (2024).
doi: 10.1016/j.bmc.2024.117714 -
D. Fonseca, et al.
One-pot microfluidics to engineer chitosan nanoparticles conjugated with antimicrobial peptides using “photoclick” chemistry: validation using the gastric bacterium Helicobacter pylori.
ACS Applied Materials & Interfaces, accepted (2024).
doi: - -
P. M. Alves, et al.
Norbornene-chitosan nanoparticles with and without a conjugated VEGF-peptide analog to promote vascularization.
Materials Chemistry Today, 36:101942 (2024).
doi: 10.1016/j.mtchem.2024.101942 | 2023 |
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L. Pereira-Dias, et al.
Peptaibiotics: harnessing the potential of microbial secondary metabolites for mitigation of plant pathogens.
Biotechnology Advances, 68:108223 (2023).
doi: 10.1016/j.biotechadv.2023.108223 -
M. Fonte, et al.
New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial leads.
European Journal of Medicinal Chemistry, 258:115575 (2023).
doi: 10.1016/j.ejmech.2023.115575 -
L. Regalado, et al.
Towards a sustainable management of the spotted-wing drosophila: disclosing the effects of two spider venom peptides on Drosophila suzukii.
Insects, 14:533 (2023).
doi: 10.3390/insects14060533 -
M. Barbosa, et al.
Influence of immobilization strategies on the antibacterial properties of antimicrobial peptide-chitosan coatings.
Pharmaceutics, 15, 1510 (2023).
doi: 10.3390/pharmaceutics15051510 -
J. R. de Almeida, et al.
Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad.
International Journal of Biological Macromolecules, 242, 124745 (2023).
doi: 10.1016/j.ijbiomac.2023.124745 -
A. R. Ferreira, et al.
The unusual aggregation and fusion activity of the antimicrobial peptide W-BP100 in anionic vesicles.
Membranes, 13(2), 138 (2023).
doi: 10.3390/membranes13020138 -
C. M. Bento, et al.
Improving the antimycobacterial drug clofazimine through formation of organic salts by combination with fluoroquinolones.
International Journal of Molecular Sciences, 24(2), 1402 (2023).
doi: 10.3390/ijms24021402 -
A. M. Ramôa et al.
Antimicrobial peptide-grafted PLGA-PEG Nanoparticles to Fight Bacterial Wound Infections.
Biomaterials Science, 11, 499-508 (2023).
doi: 10.1039/D2BM01127A -
A. Gomes et al.
Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities.
Microbiology Spectrum, , 10(4), e02291-21 (2022).
doi: 10.1128/spectrum.02291-21 -
P. Alves et al.
Thiol-norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto Chitosan to Create Antibacterial Biomaterials.
ACS Applied Polymer Materials, 4, 5012-5026 (2022).
doi: 10.1021/acsapm.2c00563 -
A. Plácido et al.
Neuroprotective effects on microglia and insights into the structure-activity relationship of an antioxidant peptide isolated from Pelophylax perezi.
Journal of Cellular and Molecular Medicine, 26, 2793-2807 (2022).
doi: 10.1111/jcmm.17292 -
A. A. Robles-Loaiza, E. A. Pinos-Tamayo, B. Mendes, J. A. Ortega-Pila, C. Proaño-Bolaños, F. Plisson, C. Teixeira, P. Gomes, J. R. Almeida
Traditional and Computational Screening of Non-Toxic Peptides and Approaches to Improving Selectivity.
Pharmaceuticals, 15:323 (2022).
doi: 10.3390/ph15030323 -
J. R. Almeida, B. Mendes, M. Lancellotti, G. Franchi, O. Passos, M. J. Ramos, P. A. Fernandes, C. Alves, N. Vale, P. Gomes, S. L. da Silva
Lessons from a single natural amino acid substitution: anticancer and antibacterial properties of two phospholipase A2-derived peptides.
Current Issues in Molecular Biology, 44, 46-62 (2022).
doi: 10.3390/cimb44010004 -
D. Fonseca, A. Moura, V. Leiro, R. Silva-Carvalho, B. N. Estevinho, C. L. Seabra, P. C. Henriques, M. Lucena, C. Teixeira, P. Gomes, P. Parreira, M. C. L. Martins
Grafting MSI-78A onto chitosan microspheres enhances its antimicrobial activity.
Acta Biomaterialia, 137, 186-198 (2022).
doi: 10.1016/j.actbio.2021.09.063 -
A. T. Silva, I. S. Oliveira, J. Gomes, L. Aguiar, D. Fontinha, D. Duarte, F. Nogueira, M. Prudêncio, E. F. Marques, C. Teixeira, R. Ferraz, P. Gomes
Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase blood-stage antimalarial activity of primaquine.
ChemMedChem, 17:e202100650 (2022).
doi: 10.1002/cmdc.202100650 -
R. J. Mendes, S. Sario, J. P. Luz, N. Tassi, C. Teixeira, P. Gomes, F. Tavares, C. Santos
Evaluation of three peptides mixtures to control the phytopathogen responsible for fire blight disease.
Plants, 10:2367 (2021).
doi: 10.3390/plants10122637 -
A. Gomes, L. J. Bessa, I. Fernandes, R. Ferraz, C. Monteiro, M. C. L. Martins, N. Mateus, P. Gameiro, C. Teixeira, P. Gomes
Disclosure of a Promising Lead to Tackle Complicated Skin and Skin Structure Infections: Antimicrobial and Antibiofilm Actions of Peptide PP4-3.1.
Pharmaceutics, 13:1962 (2021).
doi: 10.3390/pharmaceutics13111962 -
B. Costa, G. Martínez-de-Tejada, P. Gomes, M. C. L. Martins, F. Costa
Antimicrobial peptides in the battle against orthopedic implant-related infections – a review.
Pharmaceutics, 13:1918 (2021).
doi: 10.3390/pharmaceutics13111918 -
A. Gomes, L. Aguiar, R. Ferraz, C. Teixeira, P. Gomes
The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years.
International Journal of Molecular Sciences, 22:11991 (2021).
doi: 10.3390/ijms222111991 -
E. A. Barbosa et al.
The peptide secreted at the water to land transition in a model amphibian has antioxidant effects.
Proceedings of the Royal Society B: Biological Sciences, 288:20211531 (2021).
doi: 10.1098/rspb.2021.1531 -
P. Alves, C. Barrias, P. Gomes, M. C. L. Martins
Smart biomaterial-based systems for intrinsic stimuli-responsive chronic wound management.
Materials Today Chemistry, 22:100623 (2021).
doi: 10.1016/j.mtchem.2021.100623 -
M. da Silva, C. Teixeira, P. Gomes, M. Borges
Promising Drug Targets and Compounds with Anti-Toxoplasma gondii Activity.
Microorganisms, 9:1960 (2021).
doi: 10.3390/microorganisms9091960 -
A. A. Robles-Loaiza, E. A. Pinos-Tamayo, B. Mendes, C. Teixeira, C. Alves, P. Gomes, J. R. Almeida
Peptides to tackle leishmaniasis: current status and future directions.
International Journal of Molecular Sciences, 22:4400 (2021).
doi: 10.3390/ijms22094400 -
A. T. Silva, C. Teixeira, E. F. Marques, C. Prudêncio, P. Gomes, R. Ferraz
Surfing the third wave of ionic liquids: a brief review on the role of surface-active ionic liquids in drug development and delivery.
ChemMedChem, 16, 2604-2611 (2021).
doi: 10.1002/cmdc.202100215 -
R. J. Mendes, L. Regalado, J. P. Luz, N. Tassi, C. Teixeira, P. Gomes, F. Tavares, C. Santos
In vitro Evaluation of five antimicrobial peptides against the plant pathogen Erwinia amylovora.
Biomolecules, 11:554 (2021).
doi: 10.3390/biom11040554 -
G. S. Oliveira, R. P. Costa, P. Gomes, M. S. Gomes, T. Silva, C. Teixeira
Host defence peptides as potential anti-tubercular leads: a concise review.
Pharmaceuticals, 14:323 (2021).
doi: 10.3390/ph14040323 -
N. Mariz-Ponte, L. Regalado, E. Gimranov, N. Tassi, L. Moura, P. Gomes, F. Tavares, C. Santos, C. Teixeira
A Synergic Potential of Antimicrobial Peptides against Pseudomonas syringae pv. actinidiae.
Molecules, 26:1461 (2021).
doi: 10.3390/molecules26051461 -
M. Fonte, N. Tassi, P. Gomes, C. Teixeira
Acridine-based antimalarials - from the very first synthetic antimalarial to recent developments.
Molecules, 26:600 (2021).
doi: 10.3390/molecules26030600 -
A. R. Ferreira, C. Teixeira, C. F. Sousa, L. J. Bessa, P. Gomes, P. Gameiro
How insertion of a single tryptophan in the N-terminus of a cecropin A-melittin hybrid peptide changes its antimicrobial and biophysical profile.
Membranes, 11:48 (2021).
doi: 10.3390/membranes11010048 -
S. Silva, C. Alves, D. Duarte, A. Costa, B. Sarmento, A. J. Almeida, P. Gomes, N. Vale
Model amphipathic peptide coupled with Tacrine to improve its antiproliferative activity.
International Journal of Molecular Sciences, 22:242 (2021).
doi: 10.3390/ijms22010242 -
L. Aguiar, M. Pinheiro, A. R. Neves, N. Vale, S. Defaus, D. Andreu, S. Reis, P. Gomes
Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates.
Membranes, 11:4 (2021).
doi: 10.3390/membranes11010004 -
M. Fonte, N. Tassi, D. Fontinha, I. Bouzón-Arnáiz, R. Ferraz, M. J. Araújo, X. Fernández-Busquets, M. Prudêncio, P. Gomes, C. Teixeira
4,9-diaminoacridines and 4-aminoacridines as dual-stage antiplasmodial hits.
ChemMedChem, 16, 788-792 (2021).
doi: 10.1002.cmdc.202000740 - B. M. Calisto, J. Ripoll-Rozada, L. J. Dowman, C. Franck, S. M. Agten, B. L. Parker, R. Carvalho Veloso, N. Vale, P. Gomes, D. de Sanctis, R. J. Payne, P. J. B. Pereira
Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates.
Cell Chemical Biology, 28, 26-33 (2021).
doi: 10.1016/j.chembiol.2020.10.002 - A. Gomes, L. J. Bessa, P. Correia, I. Fernandes, R. Ferraz, P. Gameiro, C. Teixeira, P. Gomes
"Clicking" an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability.
International Journal of Molecular Sciences, 21:6174 (2020).
doi: 10.3390/ijms21176174 - C. Morais, A. Cardoso, L. Aguiar, N. Vale, C. Nóbrega, M. Zuzarte, P. Gomes, M. C. Pedroso de Lima, A. S. Jurado
Lauroylated histidine-enriched S413-PV peptide as an efficient gene silencing mediator in cancer cells.
Pharmaceutical Research, 37:188 (2020).
doi: 10.1007/s11095-020-02904-x - A. T. Silva, L. Lobo, I. S. Oliveira, J. Gomes, C. Teixeira, F. Nogueira, E. F. Marques, R. Ferraz, P. Gomes
Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine.
International Journal of Molecular Sciences, 21:5334 (2020).
doi: 10.3390/ijms21155334 - C. Monteiro, H. Fernandes, D. Oliveira, N. Vale, M. Barbosa, P. Gomes, M. C. L. Martins
AMP–Chitosan Coating with Bactericidal Activity in the Presence of Human Plasma Proteins.
Molecules, 25: 3046 (2020).
doi: 10.3390/molecules25133046 - M. Gütschow, et al.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 7 (editorial).
Molecules, 25: 2968 (2020).
doi: 10.3390/molecules25132968 - N. Vale, C. Alves, V. Sharma, D. F. Lázaro, S. Silva, P. Gomes, T. Fleming Outeiro
A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
Pharmacological Reports, 72, 456–464 (2020).
doi: 10.1007/s43440-019-00032-x.pdf - C. Teixeira, C. Ventura, J. R. B. Gomes, P. Gomes, F. Martins
Cinnamic derivatives as antitubercular agents: characterization by quantitative structure-activity relationship studies.
Molecules, 25:456 (2020).
doi: 10.3390/molecules25030456 - S. de Albuquerque, L. Cianni, D. de Vita, C. Duque, A. S. M. Gomes, P. Gomes, C. Laughton, A. Leitão, C. A. Montanari, R. Montanari, J. F. R. Ribeiro, J. S. da Silva, C. Teixeira
Molecular Design Aided by Random Forests and Synthesis of Potent Trypanocidal Agents as Cruzain Inhibitors for Chagas Disease Treatment.
Chemical Biology and Drug Design, 96, 948-960 (2020).
doi: 10.1111/cbdd.13663 - A. Mangoni, et al.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 6 (editorial).
Molecules, 25: 119 (2020).
doi: 10.3390/molecules25010119 - A. T. Silva, C. M. Bento, A. C. Pena, L. M. Figueiredo, C. Prudêncio, L. Aguiar, T. Silva, R. Ferraz, M. S. Gomes, C. Teixeira, P. Gomes
Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs.
Molecules, 25:66 (2020).
doi: 10.3390/molecules2501066 - L. Aguiar, A. Biosca, E. Lantero, J. Gut, N. Vale, P. J. Rosenthal, F. Nogueira, D. Andreu, X. Fernández-Busquets, P. Gomes
Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates.
Molecules, 24:4559 (2019).
doi: 10.3390/molecules24244559 - P. Parreira, C. Monteiro, V. Graça, J. Gomes, S. Maia, P. Gomes , I. C. Gonçalves, M. C. L. Martins
Surface Grafted MSI-78A Antimicrobial Peptide has High Potential for Gastric Infection Management.
Scientific Reports - Nature, 9: 18212 (2019).
doi: 10.1038/s41598-019-53918-4 - N. Mariz-Ponte, C. V. Correia, C. Teixeira, P. Gomes, C. Santos
Doença do lenho do kiwi - esca, contexto e desafios.
Agrotec, 33: 14-16 (2019).
- B. Mendes, J. R. Almeida, N. Vale, P. Gomes, F. R. Gadelha, S. L. da Silva, D. Miguel
Potential use of 13-mer peptides based on phospholipase and oligoarginine as leishmanicidal agents.
Comparative Biochemistry and Physiology, Part C, 226: 108612 (2019).
doi: 10.1016/j.cbpc.2019.108612 - A. Gomes, L. J. Bessa, I. Fernandes, R. Ferraz, N. Mateus, P. Gameiro, C. Teixeira, and P. Gomes
Turning a collagenesis-inducing peptide into a potent antibacterial and antibiofilm agent against multidrug-resistant Gram-negative bacteria.
Frontiers in Microbiology, 10: 1915 (2019).
doi: 10.3389/fmicb.2019.01915 - C. Teixeira and P. Gomes
The Xylella fastidiosa global threat: can antimicrobial peptides help in tackling this menace?
Chimica Oggi - Chemistry Today, 37, 42-44 (2019).
- C. S. M. Fernandes, A. S. Pina, A. J. M. Barbosa, I. Padrão, F. Duarte, C. Teixeira, V. Alves, P. Gomes, T. G. Fernandes, A. M. G. C. Dias, A. C. Roque
Affinity-triggered assemblies based on a designed peptide-peptide affinity pair
Biotechnology Journal, 14:1800559 (2019).
doi: 10.1002/biot.201800559 - A. Mangoni, et al.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 5 (editorial).
Molecules, 24: 2415 (2019).
doi: 10.3390/molecules24132415 - M. Fonte, N. Fagundes, A. Gomes, R. Ferraz, C. Prudêncio, M. J. Araújo, P. Gomes, C. Teixeira
Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: on the way to multi-stage antimalarials.
Tetrahedron Letters, 60, 1166-1169 (2019).
doi: 10.1016/j.tetlet.2019.03.052 - A. T. Silva, M. J. Cerqueira, C. Prudêncio, M. H. Fernandes, J. Costa-Rodrigues, C. Teixeira, P. Gomes, R. Ferraz
Antiproliferative organic salts against cancer: disclosure of an ionic liquid selective against lung and liver cells.
ACS Omega, 4, 5682-5689 (2019).
doi: 10.1021/acsomega.8b03691 - A. R. Dias, J. Costa-Rodrigues, C. Teixeira, P. Gomes, C. Prudêncio, R. Ferraz
Ionic liquids for topical delivery in cancer.
Current Medicinal Chemistry, 26, 7520-7532 (2019).
doi: 10.2174/0929867325666181026110227 - L. Aguiar, M. Machado, M. Sanches-Vaz, M. Prudêncio, N. Vale, P. Gomes
Coupling the cell-penetrating peptides Transportan and Transportan 10 to primaquine enhances its activity against liver-stage malaria parasites.
MedChemComm, 10, 221-226 (2019).
doi: 10.1039/C8MD00447A - A. Mangoni, et al.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 4 (editorial).
Molecules, 24: 130 (2019).
doi: 10.3390/molecules24010130 - J. Durão, N. Vale, S. Gomes, P., P. Gomes, C. Barrias, L. Gales
Nitric oxide release from antimicrobial peptide hydrogels for wound healing.
Biomolecules, 9:4 (2019).
doi: 10.3390/biom9010004 - M. Barbosa, F. Costa, C. Monteiro, F. Duarte, M. C. L. Martins, P. Gomes
Antimicrobial coatings prepared from Dhvar-5-click-grafted chitosan powders.
Acta Biomaterialia, 84, 242-256 (2019).
doi: 10.1016/j.actbio.2018.12.001 - J. Almeida, A. L. V. Palacios, R. S. P. Palma, B. Mendes, C. A. S. Teixeira, P. Gomes, S. L. da Silva
Harnessing snake venom phospholipases A2 to novel approaches for overcoming antibiotic resistance.
Drug Development Research, 80, 68-85 (2019).
doi: 10.1002/ddr.21456
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